I saw the movie again a couple nights ago, and it occured to me that the three bounty hunters represent the final, unrelenting natural enemies of the man who is now on the spiritual journey.
Johnny "The Kid" Pickett is the dark, negative and mischievous personalty, negative emotions and impulsiveness.
Conway Twill is the chatterbox mind, always finding associations and reasons, making up stories and distractions.
Cole Wilson, is Brutality, relentless and the ultimate enemy, eventually even destroying the other two enemies when their true natures conflicted.
All three of them had their own ailments and weaknesses also, which brought them comfort or misery, or an untimely end.
At the moment of Death, the dark brutality of Wilson meets the guardian angel of Nobody, or the death of the body meets the passage of the soul to the afterlife. and the final enemy is vanquished.

So the question is how to be attentive to these enemies, perhaps, and keep them from tracking oneself on the way to the final destination.